Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): Role of increased renal chloride reabsorption
نویسندگان
چکیده
منابع مشابه
A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism.
Aldosterone-dependent epithelial sodium transport in the distal nephron is mediated by the absorption of sodium through the highly selective, amiloride-sensitive epithelial sodium channel (ENaC) made of three homologous subunits (alpha, beta, and gamma). In human, autosomal recessive mutations of alpha, beta, or gammaENaC subunits cause pseudohypoaldosteronism type 1 (PHA-1), a renal salt-wasti...
متن کاملThe emerging role of pendrin in renal chloride reabsorption.
RENAL REABSORPTION OF SODIUM and chloride is tightly linked in most segments, often occurring even through the same transport proteins such as the Na-K-2Cl cotransporter NKCC2 or the Na-Cl cotransporter NCC in the thick ascending limb or the distal tubule, respectively (1, 6). In the proximal tubule and in parts of the collecting system, the transport of chloride and sodium is mediated by separ...
متن کاملA case of pseudohypoaldosteronism type 1 with a mutation in the mineralocorticoid receptor gene
Pseudohypoaldosteronism type 1 (PHA1) is a rare form of mineralocorticoid resistance characterized in newborns by salt wasting with dehydration, hyperkalemia and failure to thrive. This disease is heterogeneous in etiology and includes autosomal dominant PHA1 owing to mutations of the NR3C2 gene encoding the mineralocorticoid receptor, autosomal recessive PHA1 due to mutations of the epithelial...
متن کاملRenal Tubular Reabsorption of Iodide as Compared with Chloride.
The hypothesis examined in this study is that iodide reabsorption is chiefly passives occurring in the same portions of the nephron as the reabsorption of chloride and other small monovalent anions, with the ratio of the permeability of the tubule to iodide to its permeability to chloride a constant. If this were true, iodide clearance and chloride clearance would be interrelated in a uniform m...
متن کاملLife threatening hyperkalemia in a neonate with pseudo-hypoaldosteronism.
Pseudohypoaldosteronism type 1 is a rare disorder characterized by renal resistance to aldosterone which may present with a salt wasting crisis in infancy. We report a neonate with hyponatremia, severe dehydration and refractory life threatening hyperkalemia who was treated with dietary sodium chloride supplementation, potassium binding resins and fluid replacement therapy which proved to be li...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1981
ISSN: 0085-2538
DOI: 10.1038/ki.1981.72